Recombinant ALIX antibody

Catalog No. ABIN7828485

The Rabbit Monoclonal anti-ALIX antibody (Clone A493) (ABIN7828485) specifically detects ALIX in WB, IHC and IP. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Recombinant ALIX antibody (ABIN7828485)

Target: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ALIX antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Clone: A493

Product Details anti-ALIX Antibody

Purpose: Recombinant ALIX Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human ALIX fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:2000-1:10000,IHC 1:100-1:500,IP 1:25-1:50

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for ALIX

Target: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Alternative Name: ALIX

Background: AIP,DRIP,KIAA,PDCD6IP,AIP1,ALIX,DRIP4,HP95,KIAA1375,Programmed cell death 6-interacting protein (PDCD6IP), plays an important role in the endosomal sorting complexes required for transport (ESCRT) pathway in the abscission stage of cytokinesis and apoptosis. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the protein binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. It also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this protein and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 96 kDa

Observed MW: 90/100 kDa The actual band is not consistent with the expectation.

UniProt: Q8WUM4

Pathways: p53 Signaling, EGFR Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Tube Formation