Recombinant ERBB4 antibody

Catalog No. ABIN7828663

This Rabbit Monoclonal antibody specifically detects ERBB4 in IHC and IF. It exhibits reactivity toward Human.

Quick Overview for Recombinant ERBB4 antibody (ABIN7828663)

Target: ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ERBB4 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Clone: A584

Product Details anti-ERBB4 Antibody

Purpose: Recombinant HER4/ErbB4 Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human HER4/ErbB4 fragment

Isotype: IgG, kappa

Application Details

Application Notes: IHC 1:200-1:1000,IF 1:50

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for ERBB4

Target: ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))

Alternative Name: HER4/ErbB4

Background: ALS,HER,ERBB,Proto-oncogene-like protein c-ErbB,Receptor tyrosine-protein kinase erbB,Tyrosine kinase-type cell surface receptor HER,p180erbB,HER4/ErbB,ALS19,HER4,p180erbB4,ERBB4,HER4/ErbB4,Proto-oncogene-like protein c-ErbB-4,Receptor tyrosine-protein kinase erbB-4,Tyrosine kinase-type cell surface receptor HER4,4ICD,Avian erythroblastic leukemia viral oncogene homolog 4,Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4,E4ICD,EC 2.7.10.1,ERBB4 intracellular domain,HER 4,human epidermal growth factor receptor 4,Mer4,MGC138404,Oncogene ERBB4,Receptor protein tyrosine kinase erbB 4 precursor,Receptor tyrosine protein kinase erbB 4,s80HER4,Tyrosine kinase type cell surface receptor HER4,v erb a avian erythroblastic leukemia viral oncogene homolog like 4,v erb a erythroblastic leukemia viral oncogene homolog 4,Verba avian erythroblastic leukemia viral oncogene homolog like 4,Verba erythroblastic leukemia viral oncogene homolog 4,v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian),VERBB2,V-ERB-B2 avian erythroblastic leukemia viral oncogene homolog 4,HER4/ErbB4, like other receptor tyrosine kinase family members, has four ectodomains, a single transmembrane domain and a cytoplasmic tail containing the active tyrosine kinase domain. By binding to neuregulins and/or EGF family ligands, ErbB4 forms either a homodimer or heterodimer with other ErbB family members, which results in receptor activation and signaling. ErbB4 is ubiquitously expressed with the highest expression occurring in brain and heart. The expression of ErbB4 in breast cancer, pediatric brain cancer and other types of carcinomas has been reported in research studies suggesting that ErbB4 expression is involved in both normal tissue development and carcinogenesis. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

UniProt: Q15303

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway