Recombinant beta-2 Microglobulin antibody

Catalog No. ABIN7863293

The Rabbit Monoclonal anti-beta-2 Microglobulin antibody is suitable to detect beta-2 Microglobulin in samples from Human and Non-Human Primate. It has been validated for WB and IHC.

Quick Overview for Recombinant beta-2 Microglobulin antibody (ABIN7863293)

Target: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Antibody Type: Recombinant Antibody

Reactivity: Human, Non-Human Primate

Host: Rabbit

Clonality: Monoclonal

Conjugate: This beta-2 Microglobulin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: B2M-7013R

Product Details anti-beta-2 Microglobulin Antibody

Purpose: Recombinant Beta-2 Microglobulin (Renal Failure & Tumor Marker) Antibody

Specificity: Recognizes a protein of 12 kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 Molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 Molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. Beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 Molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.

Purification: 200ug/ml of Ab purified by Protein A Column.

Immunogen: Recombinant full-length human B2M protein

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for beta-2 Microglobulin

Target: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Alternative Name: Beta-2 Microglobulin

Background:

B2M, Beta 2 microglobin, Beta 2 microglobulin, Beta chain of MHC class I molecules, Beta-2-microglobulin form pI 5.3, Hdcma22p

Cervix, Endometrial, HL-60 or HeLa cells. Human carcinomas of stomach, Kidney, Lung, Spleen or Colon., Raji

Molecular Weight: 12kDa

Gene ID: 567, 534255

UniProt: P61769

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process