Recombinant Androgen Receptor antibody (AA 1-100)

Catalog No. ABIN7858051

The Rabbit Monoclonal anti-Androgen Receptor antibody (Clone DHTR-4445R) (ABIN7858051) specifically detects Androgen Receptor in IHC. The antibody is reactive with Human samples.

Quick Overview for Recombinant Androgen Receptor antibody (AA 1-100) (ABIN7858051)

Target: Androgen Receptor (AR)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Androgen Receptor antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: DHTR-4445R

Product Details anti-Androgen Receptor Antibody

Binding Specificity: AA 1-100

Purpose: Recombinant Androgen Receptor (Marker of Androgen Dependence) Antibody

Specificity: Androgen Receptor is a member of the superfamily of ligand responsive transcription regulators. The androgen receptor functions in the nucleus where it is believed to act as a transcriptional regulator mediating the action of male sex hormones.The androgen receptor has wide distribution and can be demonstrated by immunohistochemistry in several tissues including prostate, skin, and oral mucosa. Androgen receptor has been reported in a diverse range of human tumors including osteosarcoma, and in prostatic carcinoma androgen receptor expression may be of clinical relevance.Androgen Receptor is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Synthetic peptide corresponding to residues (within aa1-100) of Androgen Receptor

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Androgen Receptor

Target: Androgen Receptor (AR)

Alternative Name: Androgen Receptor

Background:

AIS, Dihydrotestosterone receptor (DHTR), HUMARA, HYSP1, Kennedy disease (KD), Nuclear receptor subfamily 3 group C member 4 (NR3C4), SMAX1, Spinal and bulbar muscular atrophy (SBMA), Testicular Feminization (TFM)

Breast, LNCap cells. Human testis, prostate or prostate carcinoma.

Molecular Weight: 110kDa

Gene ID: 367, 496240

UniProt: P10275

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding