IL-2 antibody (AA 1-153)

Catalog No. ABIN7858298

This Mouse Monoclonal antibody specifically detects IL-2 in IHC. It exhibits reactivity toward Human.

Quick Overview for IL-2 antibody (AA 1-153) (ABIN7858298)

Target: IL-2 (IL2) (Interleukin 2 (IL2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL-2 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: IL2-8712

Product Details anti-IL-2 Antibody

Binding Specificity: AA 1-153

Purpose: Interleukin-2 (IL-2) Antibody

Specificity: Interleukin-2 (IL-2) is a T cell stimulatory cytokine that induces T cell proliferation and NK cell proliferation and activation. Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). IL-2 induces CTLA-4 and also functions as a survival factor for lymphocytes.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1-153) of human IL2 protein (exact sequence is proprietary)

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for IL-2

Target: IL-2 (IL2) (Interleukin 2 (IL2))

Alternative Name: Interleukin-2

Background:

Aldesleukin, Involved in regulation of T cell clonal expansion, Lymphokine, POIL2, T-cell growth factor (TCGF)

Human thymus or tonsil tissue.

Molecular Weight: 15kDa

Gene ID: 3558, 89679

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation