PLK1 antibody (AA 1-200)

Catalog No. ABIN7858666

The Mouse Monoclonal anti-PLK1 antibody (Clone PLK1-7122) (ABIN7858666) specifically detects PLK1 in ELISA and IHC. The antibody is reactive with Human samples.

Quick Overview for PLK1 antibody (AA 1-200) (ABIN7858666)

Target: PLK1 (Polo-Like Kinase 1 (PLK1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PLK1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Clone: PLK1-7122

Product Details anti-PLK1 Antibody

Binding Specificity: AA 1-200

Purpose: PLK1 Antibody

Specificity: Plk (for polo-like kinase) encodes a serine/threonine kinase that is closely related to polo and CDC5, genes that are required for passage through mitosis in Drosophila and Saccharomyces, respectively. Polo and CDC5 both code for proteins that are involved in regulating the function of the mitotic spindle. Plk protein accumulates in the cell during the S and G2 phases of the cell cycle, Plk protein content and catalytic activity peak at the onset of mitosis, followed by a rapid reduction after mitosis. Plk expression is detectable in mitotically active tissues such as colon and placenta, as well as in tumors of various origins. It has also been suggested that Plk may serve as a marker of cell proliferation.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment of human PLK1 protein (around aa 1-200) (exact sequence is proprietary)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for PLK1

Target: PLK1 (Polo-Like Kinase 1 (PLK1))

Alternative Name: PLK1

Background:

Cell cycle regulated protein kinase, Polo like kinase 1, Serine/threonine protein kinase 13, Serine/threonine protein kinase PLK1, STPK13

Human tonsil|spleen or thymus.

Molecular Weight: 66kDa

Gene ID: 5347, 592049

UniProt: P53350

Pathways: Cell Division Cycle, M Phase