TOX3 antibody (AA 251-389)

Catalog No. ABIN7862904

The Mouse Monoclonal anti-TOX3 antibody is suitable to detect TOX3 in samples from Human. It has been validated for WB and ELISA.

Quick Overview for TOX3 antibody (AA 251-389) (ABIN7862904)

Target: TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TOX3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: TOX3-1123

Product Details anti-TOX3 Antibody

Binding Specificity: AA 251-389

Purpose: TOX3 / TNRC9 Antibody

Specificity: It recognizes a 63 kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment of human TOX3 protein (around aa 251-389) (Exact sequence is proprietary)

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for TOX3

Target: TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))

Alternative Name: TOX3

Background:

TOX3, CAG trinucleotide repeat-containing gene F9 protein, CAGF9, TOX high mobility group box family member 3, Trinucleotide repeat containing 9 (TNRC9)

A431 cell lysate (WB). Human breast or gastric carcinoma (IHC).

Molecular Weight: 63kDa

Gene ID: 27324, 460789

UniProt: O15405

Pathways: Chromatin Binding