Recombinant BAP1 antibody (AA 500-729)

Catalog No. ABIN7860335

This Rabbit Monoclonal antibody specifically detects BAP1 in IHC. It exhibits reactivity toward Human.

Quick Overview for Recombinant BAP1 antibody (AA 500-729) (ABIN7860335)

Target: BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This BAP1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: BAP1-9120R

Product Details anti-BAP1 Antibody

Binding Specificity: AA 500-729

Purpose: Recombinant BAP1 (BRCA1 Associated Protein 1) Antibody

Specificity: The BAP1 gene belongs to the ubiquitin C-terminal hydrolase subfamily of de-ubiquitination enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germ line mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, Uveal melanoma and cutaneous melanoma.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa500-729) of human BAP1 protein (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for BAP1

Target: BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))

Alternative Name: BAP1

Background:

BAP1, BRCA1 associated protein 1, Cerebral protein 13, Cerebral protein 6, HUCEP 13, Hucep 6, HUCEP13, Hucep6, TPDS, Ubiquitin carboxy terminal hydrolase, Ubiquitin carboxyl terminal hydrolase BAP1, UCHL2

Human breast or malignant mesothelioma.

Molecular Weight: 91kDa

Gene ID: 8314, 106674

UniProt: Q92560