TEK antibody (AA 700-1000)

Catalog No. ABIN7860587

This Mouse Monoclonal antibody specifically detects TEK in IHC. It exhibits reactivity toward Human.

Quick Overview for TEK antibody (AA 700-1000) (ABIN7860587)

Target: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TEK antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: TEK-9411

Product Details anti-TEK Antibody

Binding Specificity: AA 700-1000

Purpose: CD202b / TIE2 / TEK (Tyrosine Kinase with Ig and EGF Homology Domains 2) Antibody

Specificity: This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa700-1000) of human TEK protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for TEK

Target: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Alternative Name: CD202b

Background:

TIE2, VMCM, GLC3E, TIE-2, VMCM1, CD202B

Human lung, placenta or spleen.

Molecular Weight: 65kDa

Gene ID: 7010

UniProt: Q02763

Pathways: RTK Signaling, Growth Factor Binding