TMPRSS2 antibody

Catalog No. ABIN7864531

The Mouse Monoclonal anti-TMPRSS2 antibody (Clone TMPRSS2-7420) (ABIN7864531) specifically detects TMPRSS2 in IHC. The antibody is reactive with Human samples.

Quick Overview for TMPRSS2 antibody (ABIN7864531)

Target: TMPRSS2 (Transmembrane Protease, serine 2 (TMPRSS2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TMPRSS2 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: TMPRSS2-7420

Product Details anti-TMPRSS2 Antibody

Purpose: TMPRSS2 (Transmembrane Serine Protease 2) Antibody

Specificity: Extracellular proteases mediate the digestion of neighboring extracellular matrix components in initial tumor growth, allow desquamation of tumor cells into the surrounding environment, provide the basis for invasion of basement membranes in targeted metastatic organs and are required for release and activation of many growth and angiogenic factors. The TMPRSS2 gene encodes a 492 amino acid multimeric serine protease, which is mainly expressed in the mouse prostate and kidney, and is also expressed in the human small intestine, prostate, colon, stomach and salivary gland. TMPRSS2 contains several domains, including a serine protease domain of the S1 family, a scavenger receptor cysteine-rich domain of group A, an LDL receptor class A domain and a transmembrane domain. TMPRSS2 is expressed as a full length form and a cleaved protease domain and its expression is increased by androgenic hormones. TMPRSS2 is also expressed in prostate carcinoma, suggesting that it may play a role in prostate carcinogenesis.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human TMPRSS2 protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for TMPRSS2

Target: TMPRSS2 (Transmembrane Protease, serine 2 (TMPRSS2))

Alternative Name: TMPRSS2

Background:

D16Ertd61e, Epitheliasin, FLJ41954, MGC6821, PP9284, PRSS10, Serine protease 10, TMPRSS2 ETV1 FUSION GENE, INCLUDED, Transmembrane protease serine 2 catalytic chain, Transmembrane protease, serine 2, EC 3.4.219

colon|Expressed strongly in small intestine. Also expressed in prostate|stomach and salivary gland.

Molecular Weight: 70kDa

Gene ID: 7113, 439309

UniProt: O15393

Pathways: SARS-CoV-2 Protein Interactome