beta-2 Microglobulin antibody

Catalog No. ABIN7865565

The Mouse Monoclonal anti-beta-2 Microglobulin antibody is suitable to detect beta-2 Microglobulin in samples from Human. It has been validated for IHC, FACS and ELISA.

Quick Overview for beta-2 Microglobulin antibody (ABIN7865565)

Target: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This beta-2 Microglobulin antibody is un-conjugated

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS), ELISA

Clone: EBS-O-109

Product Details anti-beta-2 Microglobulin Antibody

Purpose: anti-Beta-2-microglobulin mouse monoclonal, EBS-O-109, purified

Cross-Reactivity (Details): not with non human primates

Purification: affinity chromatography

Immunogen: human PBL from a T-ALL patient

Isotype: IgG2a kappa

Application Details

Application Notes:

FACS_dilution: 0.5-1.0 μg/million cells in 0.1 ml

IHC-frozen_dilution: 1:50-1:100 (1-2 μg/mL)

elisa_dilution: assay dependent

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100 μg/mL

Buffer: PBS with 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: store at 2 - 8 °C

Target Details for beta-2 Microglobulin

Target: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Alternative Name: Beta-2-microglobulin

Background: EBS-O-109 reacts with human β-2 microglobulin, a 22 kDa protein, which associates non-covalently with the 44 kDa α1-chain of the HLA Class I complex found on all nucleated cells and on platelets. There is no reaction with erythrocytes, neither with non-human primate cells. The detection of β-2 microglobulin in body fluids has been used as a tumor marker, renal failure marker and for monitoring patients with HIV infection. Positive control: Human PBL.

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process