Recombinant FLT3 antibody (PE)

Catalog No. ABIN7867268

This Rabbit Chimeric antibody specifically detects FLT3 in FACS. It exhibits reactivity toward Human.

Quick Overview for Recombinant FLT3 antibody (PE) (ABIN7867268)

Target: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Chimeric

Conjugate: This FLT3 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Clone: 19A5

Product Details anti-FLT3 Antibody (PE)

Purpose: PE-conjugated Anti-FLT3 antibody(19A5), IgG1 Chimeric mAb

Purification: Purified from cell culture supernatant by affinity chromatography

Isotype: IgG1

Application Details

Application Notes: Flow Cyt 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid PBS with 0.05 %  Proclin300, 1 % BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2°C-8°C for 6 months

Expiry Date: 6 months

Target Details for FLT3

Target: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Alternative Name: FLT3

Background:

Synonyms: Flt-3,Flk-2,STK-1,CD135,FLK2,FLT-3

Target Background: Flt-3(Receptor-type tyrosine-protein kinase FLT3) is also known as FLK-2(Fetal liver kinase-2), STK-1(Stem cell tyrosine kinase 1), CD135. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

UniProt: P36888

Pathways: RTK Signaling