JAK1 antibody (pTyr1034, pTyr1035)

Catalog No. ABIN743333

The Rabbit Polyclonal anti-JAK1 antibody has been validated for WB, ELISA, IHC (p) and FACS. It is suitable to detect JAK1 in samples from Human and Mouse. There are 3+ publications available.

Quick Overview for JAK1 antibody (pTyr1034, pTyr1035) (ABIN743333)

Target: JAK1 (Janus Kinase 1 (JAK1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JAK1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-JAK1 Antibody

Binding Specificity: pTyr1034, pTyr1035

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Cow,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human Jak1 around the phosphorylation site of Tyr1034 + Tyr1035

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-JAK1 antibody (ABIN743333)

Huang, Zhou, Li, Ming, Li, Wu, Chen, Zhao: "In vivo and in vitro effects of microRNA-221 on hepatocellular carcinoma development and progression through the JAK-STAT3 signaling pathway by targeting SOCS3." in: Journal of cellular physiology, Vol. 234, Issue 4, pp. 3500-3514, (2019) (PubMed).

Iriyama, Hatta, Takei: "Direct effect of dasatinib on signal transduction pathways associated with a rapid mobilization of cytotoxic lymphocytes." in: Cancer medicine, Vol. 5, Issue 11, pp. 3223-3234, (2016) (PubMed).

Target Details for JAK1

Target: JAK1 (Janus Kinase 1 (JAK1))

Alternative Name: Jak1 +

Background:

Synonyms: Tyrosine-protein kinase JAK1, Janus kinase 1, JAK-1, JAK1, JAK1A, JAK1B

Background: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.

Gene ID: 3716

UniProt: P23458

Pathways: JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Hepatitis C, Toll-Like Receptors Cascades, Unfolded Protein Response