CDK5 antibody (AA 1-226)

Catalog No. ABIN7868863

The Rabbit Polyclonal anti-CDK5 antibody (ABIN7868863) specifically detects CDK5 in WB. The antibody is reactive with Zebrafish (Danio rerio) samples.

Quick Overview for CDK5 antibody (AA 1-226) (ABIN7868863)

Target: CDK5 (Cyclin-Dependent Kinase 5 (CDK5))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CDK5 Antibody

Binding Specificity: AA 1-226

Purpose: Zebrafish Cdk5 Antibody

Purification: Antigen affinity chromatography

Immunogen: An E.coli-derived zebrafish Cdk5 recombinant protein (amino acids M1-Q226) was used as the immunogen for the Zebrafish Cdk5 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Cdk5 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Cdk5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for CDK5

Target: CDK5 (Cyclin-Dependent Kinase 5 (CDK5))

Alternative Name: Cdk5

Background: CDK5, Cyclin-Dependent Kinase 5, is also known as PSSALRE. The p34 (CDC2) protein kinase regulates important transitions in the eukaryotic cell cycle. The PSSALRE expression is in all human tissues and cell lines tested. The the CDK5 gene is mapped to chromosome 7q36. Cyclin-dependent kinase-5 is predominantly expressed in neurons where it phosphorylates both high molecular weight neurofilaments and microtubule-associated protein tau. CDK5 is required for proper development of the mammalian central nervous system. To be activated, CDK5 must associate with its regulatory subunit, p35 (CDK5R1). CDK5 can phosphorylate DARPP32 at threonine-75, converting it into an inhibitor of PKA.

UniProt: Q9DE44

Pathways: Cell Division Cycle, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development, Synaptic Vesicle Exocytosis