DUSP6 antibody (AA 1-381)

Catalog No. ABIN7869275

This Rabbit Polyclonal antibody specifically detects DUSP6 in WB, ELISA, IF, FACS and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for DUSP6 antibody (AA 1-381) (ABIN7869275)

Target: DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DUSP6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-DUSP6 Antibody

Binding Specificity: AA 1-381

Purpose: DUSP6 Antibody

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids M1-T381) was used as the immunogen for the DUSP6 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the DUSP6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the DUSP6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for DUSP6

Target: DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))

Alternative Name: DUSP6

Background: Dual specificity phosphatase 6 (DUSP6) is an enzyme that in humans is encoded by the DUSP6 gene. The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene.

UniProt: Q16828

Pathways: Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades