Aurora A antibody (AA 1-395)

Catalog No. ABIN7869297

The Rabbit Polyclonal anti-Aurora A antibody is suitable to detect Aurora A in samples from Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for Aurora A antibody (AA 1-395) (ABIN7869297)

Target: Aurora A (AURKA) (Aurora Kinase A (AURKA))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Aurora A antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Aurora A Antibody

Binding Specificity: AA 1-395

Purpose: Ark-1 Antibody / Aurora-related kinase 1 / Aurka

Purification: Antigen affinity purified

Immunogen: Recombinant mouse protein (amino acids M1-S395) was used as the immunogen for the Ark-1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Ark-1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Ark-1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Aurora A

Target: Aurora A (AURKA) (Aurora Kinase A (AURKA))

Alternative Name: Ark-1

Background: AURKA (Aurora kinase A), also called ARK-1 (Aurora-related kinase 1), AurA, AIK, AURORA2, BTAK, PPP1R47, STK7, STK15, and STK6 is a mitotic centrosomal protein kinase. The main role of AURKA/ARK-1 in tumor development is in controlling chromosome segregation during mitosis. Aurora A / Aurora-related kinase 1 is a member of a family of mitotic serine/threonine kinases. The AURKA gene is overexpressed in many human cancers. Ectopic overexpression in mammalian cells induces centrosome amplification, chromosome instability, and oncogenic transformation, a phenotype characteristic of loss-of-function mutations of p53.

UniProt: P97477

Pathways: Cell Division Cycle, Asymmetric Protein Localization