BAI1 antibody (AA 1537-1567)

Catalog No. ABIN7870991

This Rabbit Polyclonal antibody specifically detects BAI1 in WB, IHC (p) and FACS. It exhibits reactivity toward Human and Mouse.

Quick Overview for BAI1 antibody (AA 1537-1567) (ABIN7870991)

Target: BAI1 (Brain-Specific Angiogenesis Inhibitor 1 (BAI1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BAI1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-BAI1 Antibody

Binding Specificity: AA 1537-1567

Purpose: Brain-specific angiogenesis inhibitor 1 Antibody / BAI1

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 1537-1567 from the human protein was used as the immunogen for the Brain-specific angiogenesis inhibitor 1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Brain-specific angiogenesis inhibitor 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Brain-specific angiogenesis inhibitor 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for BAI1

Target: BAI1 (Brain-Specific Angiogenesis Inhibitor 1 (BAI1))

Alternative Name: Brain-specific angiogenesis inhibitor 1

Background: Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas.

UniProt: O14514

Pathways: p53 Signaling