GZMB antibody (AA 175-203)

Catalog No. ABIN7871301

The Rabbit Polyclonal anti-GZMB antibody is suitable to detect GZMB in samples from Human. It has been validated for WB, FACS and IHC (p).

Quick Overview for GZMB antibody (AA 175-203) (ABIN7871301)

Target: GZMB (Granzyme B (GZMB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GZMB antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GZMB Antibody

Binding Specificity: AA 175-203

Purpose: GZMB Antibody / Granzyme B

Purification: Purified

Immunogen: A portion of amino acids 175-203 from the human protein was used as the immunogen for the GZMB antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the GZMB antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the GZMB antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for GZMB

Target: GZMB (Granzyme B (GZMB))

Alternative Name: GZMB

Background: Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.

UniProt: P10144

Pathways: Apoptosis, Caspase Cascade in Apoptosis