MUTYH antibody (AA 187-528)

Catalog No. ABIN7871513

This Rabbit Polyclonal antibody specifically detects MUTYH in WB, ELISA and FACS. It exhibits reactivity toward Human and Rat.

Quick Overview for MUTYH antibody (AA 187-528) (ABIN7871513)

Target: MUTYH (MutY Homolog (E. Coli) (MUTYH))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MUTYH antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-MUTYH Antibody

Binding Specificity: AA 187-528

Purpose: MUTYH Antibody / Adenine DNA glycosylase / MYH1

Purification: Antigen affinity purified

Immunogen: An E.coli-derived human recombinant protein (amino acids A187-N528) was used as the immunogen for the MUTYH antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the MUTYH antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the MUTYH antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for MUTYH

Target: MUTYH (MutY Homolog (E. Coli) (MUTYH))

Alternative Name: MUTYH

Background: This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene.

UniProt: Q9UIF7

Pathways: DNA Damage Repair