ATM antibody (AA 1900-2500)

Catalog No. ABIN7871650

The Mouse Monoclonal anti-ATM antibody (Clone ATM-9472) (ABIN7871650) specifically detects ATM in IHC (p). The antibody is reactive with Human samples.

Quick Overview for ATM antibody (AA 1900-2500) (ABIN7871650)

Target: ATM (Ataxia Telangiectasia Mutated (ATM))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ATM antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: ATM-9472

Product Details anti-ATM Antibody

Binding Specificity: AA 1900-2500

Purpose: ATM Antibody / Ataxia telangiectasia mutated (azide and preservative free)

Purification: Protein A affinity

Immunogen: A portion of amino acids 1900-2500 from human ATM protein was used as the immunogen for the ATM antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the ATM antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the ATM antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for ATM

Target: ATM (Ataxia Telangiectasia Mutated (ATM))

Alternative Name: ATM

Background: The phosphatidylinositol kinase (PIK) family members fall into two distinct subgroups. The first subgroup contains proteins such as the PI 3- and PI 4-kinases and the second group comprises the PIK-related kinases. The PIK-related kinases include Atm, DNA-PKCS and FRAP. These proteins have in common a region of homology at their carboxy-termini that is not present in the PI 3- and PI 4-kinases. The Atm gene is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) that is characterized by cerebellar degeneration (ataxia) and the appearance of dilated blood vessels (telangiec-tases) in the conjunctivae of the eyes. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction.

UniProt: Q13315

Pathways: p53 Signaling, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus