PON1 antibody (AA 20-252)

Catalog No. ABIN7871850

The Rabbit Polyclonal anti-PON1 antibody is suitable to detect PON1 in samples from Human, Mouse, Rat and Monkey. It has been validated for WB, ELISA and IHC (p).

Quick Overview for PON1 antibody (AA 20-252) (ABIN7871850)

Target: PON1 (Paraoxonase 1 (PON1))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PON1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PON1 Antibody

Binding Specificity: AA 20-252

Purpose: Paraoxonase 1 Antibody / PON1

Purification: Affinity purified

Immunogen: Recombinant human protein (amino acids H20-A252) was used as the immunogen for the Paraoxonase 1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Paraoxonase 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Paraoxonase 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PON1

Target: PON1 (Paraoxonase 1 (PON1))

Alternative Name: Paraoxonase 1

Background: Serum paraoxonase/arylesterase 1 (PON1), also known as aromatic esterase 1, is an enzyme that in humans is encoded by the PON1 gene. It is mapped to 7q21.3. This gene has esterase and more specifically paraoxonase activity. PON1 is responsible for hydrolysing organophosphate pesticides and nerve gasses. Polymorphisms in the PON1 gene significantly affect the catalytic ability of the enzyme. PON1 (paraoxonase 1) is also a major anti-atherosclerotic component of high-density lipoprotein (HDL). The PON1 gene is activated by PPAR-?, which increases synthesis and release of paraoxonase 1 enzyme from the liver, reducing atherosclerosis.

UniProt: P27169