MCM6 antibody (AA 228-368)

Catalog No. ABIN7872425

This Mouse Monoclonal antibody specifically detects MCM6 in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for MCM6 antibody (AA 228-368) (ABIN7872425)

Target: MCM6 (Minichromosome Maintenance Complex Component 6 (MCM6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MCM6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: MCM6-3000

Product Details anti-MCM6 Antibody

Binding Specificity: AA 228-368

Purpose: MCM6 Antibody

Purification: Protein G affinity chromatography

Immunogen: A recombinant human partial protein (amino acids 228-368) was used as the immunogen for this MCM6 antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the MCM6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the MCM6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for MCM6

Target: MCM6 (Minichromosome Maintenance Complex Component 6 (MCM6))

Alternative Name: MCM6

Background: The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM6 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1/S phase. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP-dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the post-replicative state of the cell. MCM2/MCM6 complexes function as substrates for Cdc2/cyclin B in vitro.

UniProt: Q14566

Pathways: DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA