STS antibody (AA 24-193)

Catalog No. ABIN7872671

This Rabbit Polyclonal antibody specifically detects STS in WB, ELISA, FACS and IF. It exhibits reactivity toward Mouse.

Quick Overview for STS antibody (AA 24-193) (ABIN7872671)

Target: STS (Steroid Sulfatase (STS))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STS antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF)

Product Details anti-STS Antibody

Binding Specificity: AA 24-193

Purpose: Asc Antibody / Pycard / Tms1

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant mouse protein (amino acids K24-S193) was used as the immunogen for the Asc antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Asc antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Asc antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for STS

Target: STS (Steroid Sulfatase (STS))

Alternative Name: Asc

Background: PYCARD, often referred to as ASC (Apoptosis-associated speck-like protein containing a CARD), is a protein that in humans is encoded by the PYCARD gene. This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm, however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.

UniProt: Q9EPB4

Pathways: Steroid Hormone Biosynthesis, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation