Huntingtin antibody (AA 3079-3142)

Catalog No. ABIN7873734

The Rabbit Polyclonal anti-Huntingtin antibody is suitable to detect Huntingtin in samples from Human. It has been validated for ELISA and IHC (p).

Quick Overview for Huntingtin antibody (AA 3079-3142) (ABIN7873734)

Target: Huntingtin (HTT)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Huntingtin antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Huntingtin Antibody

Binding Specificity: AA 3079-3142

Purpose: HTT Antibody / Huntingtin

Purification: Antigen affinity chromatography

Immunogen: An E.coli-derived human recombinant protein (amino acids R3079-C3142) was used as the immunogen for the HTT antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the HTT antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the HTT antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Huntingtin

Target: Huntingtin (HTT)

Alternative Name: HTT

Background: The huntingtin gene, also called HTT or HD (Huntington disease) gene, is the IT15 (interesting transcript 15) gene which codes for a protein called the huntingtin protein. It is mapped to 4p16.3. The protein has no sequence homology with other proteins and is highly expressed in neurons and tests in humans and rodents. HTT upregulates the expression of Brain Derived Neurotrophic Factor (BDNF) at the transcription level, and this gene is required for normal development. The HTT protein is involved in vesicle trafficking as it interacts with HIP1, a clathrin-binding protein, to mediate endocytosis, the absorption of materials into a cell. HTT was also visualized as punctate staining likely to represent nerve endings. What's more, wildtype HTT may function in the nucleus in the assembly of nuclear matrix-bound protein complexes involved with transcriptional repression and RNA processing.

UniProt: P42858

Pathways: PI3K-Akt Signaling, Hormone Transport, Transition Metal Ion Homeostasis, Tube Formation, Protein targeting to Nucleus, Dicarboxylic Acid Transport