Recombinant BAP1 antibody (AA 400-729)

Catalog No. ABIN7874799

The Rabbit Monoclonal anti-BAP1 antibody is suitable to detect BAP1 in samples from Human. It has been validated for IHC (p).

Quick Overview for Recombinant BAP1 antibody (AA 400-729) (ABIN7874799)

Target: BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This BAP1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: BAP1-9795R

Product Details anti-BAP1 Antibody

Binding Specificity: AA 400-729

Purpose: BAP1 Antibody / BRCA1-Associated Protein 1 (azide and preservative free)

Purification: Protein A affinity

Immunogen: A portion of amino acids 400-729 from human BRCA1-Associated Protein 1 protein was used as the immunogen for the BAP1 antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the BAP1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the BAP1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for BAP1

Target: BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))

Alternative Name: BAP1

Background: The BAP1 gene belongs to the ubiquitin C-terminal hydrolase subfamily of de-ubiquitination enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germ line mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, Uveal melanoma and cutaneous melanoma.

UniProt: Q92560