FLT3 antibody (AA 500-800)

Catalog No. ABIN7875479

This Mouse Monoclonal antibody specifically detects FLT3 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for FLT3 antibody (AA 500-800) (ABIN7875479)

Target: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FLT3 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: FLT3-9888

Product Details anti-FLT3 Antibody

Binding Specificity: AA 500-800

Purpose: CD135 Antibody / FLT3 (azide and preservative free)

Purification: Protein G affinity

Immunogen: A portion of amino acids 500-800 from human FLT3 protein was used as the immunogen for the CD135 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the CD135 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the CD135 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for FLT3

Target: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Alternative Name: CD135

Background: Stem cell tyrosine kinase (STK-1) has been cloned from a CD34+ hematopoietic stem cell enriched library and identified as the human homolog of a previously identified gene of Mouse origin designated either Flk-2 or Flt-3. The STK-1 cDNA encodes a protein of 993 amino acids with 85 % identity to Flt-3/Flk-2. STK-1 is a member of the type III receptor tyrosine kinase family that includes Kit (steel factor receptor), Fms and PDGF. STK-1 expression in blood and marrow is restricted to CD34+ cells, a population greatly enriched for hematopoietic stem/progenitor cells. STK-1 antiserum recognizes two polypeptides in these cells. The Mouse homolog of STK-1, designated Flt-3/Flk-2, is expressed at high levels in hematopoietic cells and also in neural, gonadal, hepatic and placental tissues. It has been suggested that STK-1 and its murine homolog Flt-3/Flk-2 may function as growth factor receptors on hematopoietic stem and/or progenitor cells.

UniProt: P36888

Pathways: RTK Signaling