WFS1 antibody (AA 61-313)

Catalog No. ABIN7876107

The Rabbit Polyclonal anti-WFS1 antibody is suitable to detect WFS1 in samples from Human and Monkey. It has been validated for WB, ELISA, IF, IHC (p) and FACS.

Quick Overview for WFS1 antibody (AA 61-313) (ABIN7876107)

Target: WFS1 (Wolfram Syndrome 1 (WFS1))

Reactivity: Human, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WFS1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-WFS1 Antibody

Binding Specificity: AA 61-313

Purpose: Wolframin Antibody / WFS1

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids A61-H313) was used as the immunogen for the Wolframin antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Wolframin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Wolframin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for WFS1

Target: WFS1 (Wolfram Syndrome 1 (WFS1))

Alternative Name: Wolframin

Background: Wolframin is a protein that in humans is encoded by the WFS1 gene. This gene encodes a transmembrane protein, which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Mutations in this gene are associated with Wolfram syndrome, also called DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), an autosomal recessive disorder. The disease affects the brain and central nervous system. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38. Alternatively spliced transcript variants have been found for this gene.

UniProt: O76024

Pathways: Sensory Perception of Sound, Carbohydrate Homeostasis, ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interactome