Angiotensin I Converting Enzyme 1 antibody (AA 652-788)

Catalog No. ABIN7876319

This Mouse Monoclonal antibody specifically detects Angiotensin I Converting Enzyme 1 in WB, ELISA and IHC (p). It exhibits reactivity toward Human.

Quick Overview for Angiotensin I Converting Enzyme 1 antibody (AA 652-788) (ABIN7876319)

Target: Angiotensin I Converting Enzyme 1 (ACE) (Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Angiotensin I Converting Enzyme 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: ACE-3762

Product Details anti-Angiotensin I Converting Enzyme 1 Antibody

Binding Specificity: AA 652-788

Purpose: ACE Antibody / Angiotensin I Converting Enzyme

Purification: Protein G affinity chromatography

Immunogen: A portion of amino acids 652-788 from the human protein was used as the immunogen for the ACE antibody.

Isotype: IgG2c, kappa

Application Details

Application Notes: Optimal dilution of the ACE antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the ACE antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Angiotensin I Converting Enzyme 1

Target: Angiotensin I Converting Enzyme 1 (ACE) (Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE))

Alternative Name: ACE

Background: This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes - the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.

UniProt: P12821

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration