ERC1 antibody (AA 721-1116)

Catalog No. ABIN7876644

The Rabbit Polyclonal anti-ERC1 antibody is suitable to detect ERC1 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA, IP, IF, FACS and ICC.

Quick Overview for ERC1 antibody (AA 721-1116) (ABIN7876644)

Target: ERC1 (ELKS/RAB6-Interacting/CAST Family Member 1 (ERC1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERC1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Product Details anti-ERC1 Antibody

Binding Specificity: AA 721-1116

Purpose: ERC1 Antibody / ELKS/RAB6-interacting/CAST family member 1

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human ERC1 recombinant protein (Position: H721-S1116) was used as the immunogen for the ERC1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the ERC1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the ERC1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for ERC1

Target: ERC1 (ELKS/RAB6-Interacting/CAST Family Member 1 (ERC1))

Alternative Name: ERC1

Background: ERC1 antibody detects ELKS/RAB6-interacting/CAST family member 1, encoded by the ERC1 gene. ERC1 is a scaffolding protein localized at presynaptic active zones, where it organizes signaling complexes and regulates neurotransmitter release. ERC1 antibody provides researchers with a useful reagent to study synaptic transmission, active zone assembly, and neuronal signaling.

ERC1 contains coiled-coil domains that mediate interactions with multiple active zone proteins, including RIM, Munc13, and Bassoon. Research using ERC1 antibody has shown that it anchors voltage-gated calcium channels and synaptic vesicle machinery at release sites. This organization ensures efficient neurotransmitter release in response to action potentials. Without ERC1, active zones are structurally disorganized, impairing synaptic transmission.

Studies with ERC1 antibody have demonstrated that it also participates in vesicle trafficking. ERC1 interacts with Rab6 and regulates transport of vesicle precursors to synaptic terminals. This trafficking function integrates with its scaffolding role, ensuring proper delivery and assembly of presynaptic components. These findings highlight ERC1 as a central organizer of synaptic release machinery.

Dysregulation of ERC1 has been associated with neurological disease. Research using ERC1 antibody has linked altered expression to autism spectrum disorders, epilepsy, and schizophrenia. By disrupting active zone architecture, mutations or expression changes in ERC1 impair synaptic connectivity and neuronal communication. ERC1 fusions with other genes have also been identified in cancers, linking synaptic scaffolding proteins to oncogenesis.

ERC1 antibody is commonly used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting quantifies ERC1 expression in neuronal and non-neuronal tissues, immunohistochemistry identifies localization in brain tissue, and immunofluorescence highlights colocalization with active zone proteins. These applications make ERC1 antibody valuable in neuroscience and disease research.

By supplying validated ERC1 antibody reagents, NSJ Bioreagents supports studies into synaptic organization, neurotransmitter release, and disease. Detection of ELKS/RAB6-interacting/CAST family member 1 provides researchers with insight into how scaffolding proteins regulate synaptic architecture.

UniProt: Q8IUD2

Pathways: SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection