Recombinant GZMB antibody (AA 73-187)

Catalog No. ABIN7876651

The Rabbit Monoclonal anti-GZMB antibody (Clone GZMB-4539R) (ABIN7876651) specifically detects GZMB in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant GZMB antibody (AA 73-187) (ABIN7876651)

Target: GZMB (Granzyme B (GZMB))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This GZMB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: GZMB-4539R

Product Details anti-GZMB Antibody

Binding Specificity: AA 73-187

Purpose: Recombinant Granzyme B Antibody

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 73-187 was used as the immunogen for the recombinant Granzyme B antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the recombinant Granzyme B antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the recombinant Granzyme B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for GZMB

Target: GZMB (Granzyme B (GZMB))

Alternative Name: Granzyme B

Background: Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin s Disease.

UniProt: P10144

Pathways: Apoptosis, Caspase Cascade in Apoptosis