Recombinant GZMB antibody (AA 73-187)

Catalog No. ABIN7876653

The Mouse Monoclonal anti-GZMB antibody is suitable to detect GZMB in samples from Human. It has been validated for WB and IHC (p).

Quick Overview for Recombinant GZMB antibody (AA 73-187) (ABIN7876653)

Target: GZMB (Granzyme B (GZMB))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GZMB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RGZMB-4538

Product Details anti-GZMB Antibody

Binding Specificity: AA 73-187

Purpose: Recombinant GZMB Antibody / Granzyme B

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 73-187 was used as the immunogen for the recombinant GZMB antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the recombinant GZMB antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the recombinant GZMB antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for GZMB

Target: GZMB (Granzyme B (GZMB))

Alternative Name: GZMB

Background: Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin s Disease.

UniProt: P10144

Pathways: Apoptosis, Caspase Cascade in Apoptosis