GZMB antibody (AA 73-187)

Catalog No. ABIN7876664

This Mouse Monoclonal antibody specifically detects GZMB in IHC (p). It exhibits reactivity toward Human.

Quick Overview for GZMB antibody (AA 73-187) (ABIN7876664)

Target: GZMB (Granzyme B (GZMB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GZMB antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: GZMB-3055

Product Details anti-GZMB Antibody

Binding Specificity: AA 73-187

Purpose: Granzyme B Antibody

Purification: Protein G affinity chromatography

Immunogen: A recombinant human partial protein (amino acids 73-187) was used as the immunogen for the Granzyme B antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Granzyme B antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Granzyme B antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for GZMB

Target: GZMB (Granzyme B (GZMB))

Alternative Name: Granzyme B

Background: Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin's Disease.

UniProt: P10144

Pathways: Apoptosis, Caspase Cascade in Apoptosis