GZMB antibody (AA 73-187)

Catalog No. ABIN7876665

The Mouse Monoclonal anti-GZMB antibody is suitable to detect GZMB in samples from Human. It has been validated for WB and IHC (p).

Quick Overview for GZMB antibody (AA 73-187) (ABIN7876665)

Target: GZMB (Granzyme B (GZMB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GZMB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: GZB-1

Product Details anti-GZMB Antibody

Binding Specificity: AA 73-187

Purpose: Granzyme B Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: Amino acids 73-187 were used as the immunogen for the Granzyme B antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the Granzyme B antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the Granzyme B antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for GZMB

Target: GZMB (Granzyme B (GZMB))

Alternative Name: Granzyme B

Background: This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. [UniProt]

UniProt: P10144

Pathways: Apoptosis, Caspase Cascade in Apoptosis