CDKN1C antibody (full length)

Catalog No. ABIN7878085

The Mouse Monoclonal anti-CDKN1C antibody (Clone KIP2-7187) (ABIN7878085) specifically detects CDKN1C in IHC (p). The antibody is reactive with Human samples.

Quick Overview for CDKN1C antibody (full length) (ABIN7878085)

Target: CDKN1C (Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CDKN1C antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: KIP2-7187

Product Details anti-CDKN1C Antibody

Binding Specificity: full length

Purpose: p57Kip2 Antibody

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human p57Kip2 protein was used as the immunogen for the p57Kip2 antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the p57Kip2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the p57Kip2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CDKN1C

Target: CDKN1C (Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C))

Alternative Name: p57Kip2

Background: Recognizes a protein of 57 kDa, identified as p57Kip2. It shows no cross-reaction with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. Anti-p57 has been used as an aide in identification of complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts and stromal cells) from partial hydatidiform mole (PHM) in which both cytotrophoblasts and stromal cells stain. The histological differentiation of complete mole, partial mole, and hydropic spontaneous abortion is problematic. Most complete hydatidiform moles are diploid, whereas most partial moles are triploid. Ploidy studies will identify partial moles, but will not differentiate complete moles from non-molar gestations. Complete moles carry a high risk of persistent disease and choriocarcinoma, while partial moles have a very low risk. In normal placenta, many cytotrophoblast nuclei and stromal cells are labeled with this antibody. Similar findings apply to PHM and hydropic abortus tissues. Intervillous trophoblastic islands (IVTIs) demonstrate nuclear labeling in all three entities and serve as an internal control.

UniProt: P49918

Pathways: Cell Division Cycle, Dopaminergic Neurogenesis