STAT5B antibody (full length)

Catalog No. ABIN7879042

The Mouse Monoclonal anti-STAT5B antibody (Clone STAT5B-2657) (ABIN7879042) specifically detects STAT5B in ELISA. The antibody is reactive with Human samples.

Quick Overview for STAT5B antibody (full length) (ABIN7879042)

Target: STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This STAT5B antibody is un-conjugated

Application: ELISA

Clone: STAT5B-2657

Product Details anti-STAT5B Antibody

Binding Specificity: full length

Purpose: STAT5b Antibody

Purification: Protein G affinity chromatography

Immunogen: A recombinant full-length human STAT5B protein was used as the immunogen for this STAT5b antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the STAT5b antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the STAT5b antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for STAT5B

Target: STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))

Alternative Name: STAT5b

Background: Signal transducer and activator of transcription 5A (Stat5a) and Stat5b, which share 96 % homology, undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors, and then form homo- or heterodimers that translocate to the nucleus, where they initiate transcription. Activation of Stat5a via IL-2, IL-3, IL-7/ GM-CSF, erythropoietin, thrombopoietin and growth hormones influences proliferation, differentiation and apoptosis in lymphohematopoietic cells. Phosphorylation of Stat5a at Ser127/Ser128 and Ser779 are contigent on ErbB-4-mediated activation of Stat5a. Activation of Stat5b via IL-2, IL-4, CSF-1 and growth hormones influences TCR signaling, apoptosis, adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with the retinoic acid receptor a gene in acute promyelocytic leukemias (APLL). Stat5a/b null mice have severely impaired lymphoid development and differentiation.

UniProt: P51692

Pathways: JAK-STAT Signaling, RTK Signaling, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation