TMPRSS2 antibody (full length)

Catalog No. ABIN7879197

The Mouse Monoclonal anti-TMPRSS2 antibody is suitable to detect TMPRSS2 in samples from Human. It has been validated for IHC (p).

Quick Overview for TMPRSS2 antibody (full length) (ABIN7879197)

Target: TMPRSS2 (Transmembrane Protease, serine 2 (TMPRSS2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TMPRSS2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: TMPRSS2-7420

Product Details anti-TMPRSS2 Antibody

Binding Specificity: full length

Purpose: Transmembrane protease serine 2 Antibody / TMPRSS2 (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human protein was used as the immunogen for the Transmembrane protease serine 2 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Transmembrane protease serine 2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the Transmembrane protease serine 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for TMPRSS2

Target: TMPRSS2 (Transmembrane Protease, serine 2 (TMPRSS2))

Alternative Name: Transmembrane protease serine 2

Background: Extracellular proteases mediate the digestion of neighboring extracellular matrix components in initial tumor growth, allow desquamation of tumor cells into the surrounding environment, provide the basis for invasion of basement membranes in targeted metastatic organs and are required for release and activation of many growth and angiogenic factors. The TMPRSS2 gene encodes a 492 amino acid multimeric serine protease, which is mainly expressed in the mouse prostate and kidney, and is also expressed in the human small intestine, prostate, colon, stomach and salivary gland. TMPRSS2 contains several domains, including a serine protease domain of the S1 family, a scavenger receptor cysteine-rich domain of group A, an LDL receptor class A domain and a transmembrane domain. TMPRSS2 is expressed as a full length form and a cleaved protease domain and its expression is increased by androgenic hormones. TMPRSS2 is also expressed in prostate carcinoma, suggesting that it may play a role in prostate carcinogenesis.

UniProt: O15393

Pathways: SARS-CoV-2 Protein Interactome