Recombinant p40 (p63 Delta) (N-Term) antibody

Catalog No. ABIN7879640

This Rabbit Monoclonal antibody specifically detects p40 (p63 Delta) in FACS, IF and IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant p40 (p63 Delta) (N-Term) antibody (ABIN7879640)

Target: p40 (p63 Delta)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: TP40-3980R

Product Details

Binding Specificity: N-Term

Purpose: Recombinant p40 Antibody / deltaNp63 (azide and preservative free)

Purification: Protein A affinity chromatography

Immunogen: A synthetic peptide from the N-terminal of human p40 protein was used as the immunogen for the p40 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the recombinant p40 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the recombinant p40 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details

Target: p40 (p63 Delta)

Alternative Name: p40

Background: P63 consists of two major isoforms-TAp63 and delta-Np63. These isoforms differ in the structure of the N-terminal domains. The TAp63 isoform (identified by anti-p63 antibody) contains a transactivation-competent TA domain with homology to p53, which regulates the expression of the growth-inhibitory genes. In contrast, DNp63 isoform (identified by anti-p40 antibody) contains an alternative transcriptionally-inactive delta-N domain, which antagonizes the activity of TAp63 and p53. P40/3980R recognizes exclusively delta-Np63 but not TAp63. p40 is a squamous cell carcinoma specific antibody. It reacts with the vast majority of cases of squamous cell carcinomas of various origins, but not with adenocarcinomas. It is particularly useful in differentiating lung squamous cell carcinoma from lung poorly differentiated adenocarcinoma. p40 antibody can also be used as an alternative basal cell/myoepithelial cell marker, which has similar sensitivity and specificity as that of p63 antibody. Therefore, p40 antibody may also be used as an alternative immunohistochemical marker for determining prostate adenocarcinoma vs. benign prostate glands and for determining breast intraductal carcinoma vs. invasive breast ductal carcinoma.

UniProt: Q9H3D4