CDKN1C antibody

Catalog No. ABIN7880550

The Rabbit Polyclonal anti-CDKN1C antibody is suitable to detect CDKN1C in samples from Human. It has been validated for WB.

Quick Overview for CDKN1C antibody (ABIN7880550)

Target: CDKN1C (Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDKN1C antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CDKN1C Antibody

Purpose: CDKN1C Antibody / p57 Kip2

Sequence: AAIKKLSGPL ISDFFAKRKR

Purification: Affinity purified

Immunogen: Amino acids AAIKKLSGPLISDFFAKRKR from the human protein were used as the immunogen for the CDKN1C antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CDKN1C antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the CDKN1C antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for CDKN1C

Target: CDKN1C (Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C))

Alternative Name: CDKN1C

Background: Cyclin-dependent kinase inhibitor 1C (p57 Kip2), also known as CDKN1C, is a protein which in humans is encoded by the CDKN1C imprinted gene. It is mapped to 11p15.4. This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.

UniProt: P49918

Pathways: Cell Division Cycle, Dopaminergic Neurogenesis