DCLK1 antibody

Catalog No. ABIN7880654

This Rabbit Monoclonal antibody specifically detects DCLK1 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for DCLK1 antibody (ABIN7880654)

Target: DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This DCLK1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: AAFA-4

Product Details anti-DCLK1 Antibody

Purpose: DCLK1 Antibody / Doublecortin-like kinase 1

Purification: Affinity purified

Immunogen: A synthetic peptide specific to human Doublecortin-like kinase 1 was used as the immunogen for the DCLK1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the DCLK1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the DCLK1 antibody at -20oC.

Target Details for DCLK1

Target: DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))

Alternative Name: DCLK1

Background: The DCKL1 gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities. [RefSeq]

UniProt: O15075