GZMB antibody

Catalog No. ABIN7880924

This Rabbit Monoclonal antibody specifically detects GZMB in IHC (p). It exhibits reactivity toward Human.

Quick Overview for GZMB antibody (ABIN7880924)

Target: GZMB (Granzyme B (GZMB))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This GZMB antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: AAHC-7

Product Details anti-GZMB Antibody

Purpose: Granzyme B Antibody

Purification: Affinity purified

Immunogen: A synthetic peptide specific to human Granzyme B / GZMB was used as the immunogen for the Granzyme B antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Granzyme B antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the Granzyme B antibody at -20oC.

Target Details for GZMB

Target: GZMB (Granzyme B (GZMB))

Alternative Name: Granzyme B

Background: This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.

UniProt: P10144

Pathways: Apoptosis, Caspase Cascade in Apoptosis