IFNA1 antibody

Catalog No. ABIN7881251

This Mouse Monoclonal antibody specifically detects IFNA1 in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for IFNA1 antibody (ABIN7881251)

Target: IFNA1 (Interferon, alpha 1 (IFNA1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IFNA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: IFNA-6689

Product Details anti-IFNA1 Antibody

Purpose: Interferon alpha 1 Antibody / IFNA1

Purification: Protein A/G affinity

Immunogen: Recombinant human IFNA1 protein was used as the immunogen for the Interferon alpha 1 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Interferon alpha 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Interferon alpha 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for IFNA1

Target: IFNA1 (Interferon, alpha 1 (IFNA1))

Alternative Name: Interferon alpha 1

Background: This MAb is specific for human interferon alpha 1 and does not cross react with human interferon alpha 2. Interferons are widely used therapeutic agents because of their anti-tumor and anti-viral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 Interferon- Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is influenced by phosphorylation of Serine 535 and 539 in the IFNAR1.Produced by macrophages, IFN-alphas have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase

UniProt: P01562

Pathways: JAK-STAT Signaling, Hepatitis C