ROR2 antibody

Catalog No. ABIN7882146

This Mouse Monoclonal antibody specifically detects ROR2 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for ROR2 antibody (ABIN7882146)

Target: ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ROR2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: ROR2-1911

Product Details anti-ROR2 Antibody

Purpose: ROR2 Antibody

Purification: Protein G affinity chromatography

Immunogen: Cultured human keratinocytes were used as the immunogen for this ROR2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the ROR2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the ROR2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for ROR2

Target: ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))

Alternative Name: ROR2

Background: ROR2 (receptor tyrosine kinase-like orphan receptor 2), also known as neurotrophic tyrosine kinase receptor-related 2 (NTRKR2), is a single pass transmembrane tyrosine-protein kinase receptor. It contains a cytoplasmic tyrosine kinase domain, distally located serine-threonine-rich domains, an extracellular immunoglobulin-like domain, a cysteine-rich domain and a kringle domain. ROR2 is important for skeletal and endocrine development and is required for cartilage and growth plate development. It promotes the differentiation of osteoblasts and plays an important role in the early formation of chondrocytes. ROR2 sequesters and associates with Dlxin-1 affecting the transcriptional function of Msx-2. ROR2 also interacts with canoncial Wnt-1 and Wnt-3, regulating their signaling pathways. Defects in ROR2 can result in the autosomal dominant skeletal disorder, brachydactyly type B1, or the autosomal recessive skeletal disorder, Robinow syndrome.

UniProt: Q01974

Pathways: RTK Signaling, WNT Signaling