TLR8 antibody

Catalog No. ABIN7882501

The Rabbit Polyclonal anti-TLR8 antibody is suitable to detect TLR8 in samples from Human. It has been validated for IHC (p).

Quick Overview for TLR8 antibody (ABIN7882501)

Target: TLR8 (Toll-Like Receptor 8 (TLR8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TLR8 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-TLR8 Antibody

Purpose: Toll-like receptor 8 Antibody / TLR8

Sequence: RLQEVPQTVG KYVTELDL

Purification: Affinity purified

Immunogen: Amino acids RLQEVPQTVGKYVTELDL from the human protein were used as the immunogen for the Toll-like receptor 8 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Toll-like receptor 8 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Toll-like receptor 8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for TLR8

Target: TLR8 (Toll-Like Receptor 8 (TLR8))

Alternative Name: Toll-like receptor 8

Background: TLR8 (Toll-like receptor 8) is a protein that in humans is encoded by the TLR8 gene. TLR8 has also been designated as CD288 (cluster of differentiation 288).The TLR8 gene is mapped to Xp22.3-p22.2 by Chuang and Ulevitch (2000) and Du et al. (2000). The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. TLR8 recognizes G-rich oligonucleotides.

UniProt: Q9NR97

Pathways: TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades