Calcitonin Receptor antibody (1st Extracellular Loop)

Catalog No. ABIN7884806

The Rabbit Polyclonal anti-Calcitonin Receptor antibody (ABIN7884806) specifically detects Calcitonin Receptor in WB, IF, IC and LCI. The antibody is reactive with Rat and Mouse samples.

Quick Overview for Calcitonin Receptor antibody (1st Extracellular Loop) (ABIN7884806)

Target: Calcitonin Receptor (CALCR)

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Calcitonin Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunochromatography (IC), Live Cell Imaging (LCI)

Grade: Carrier-free

Product Details anti-Calcitonin Receptor Antibody

Binding Specificity: 1st Extracellular Loop, AA 201-215

Purpose: A Rabbit Polyclonal Antibody to Calcitonin Receptor

Predicted Reactivity: Mouse - identical, human - 14,15 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)HLVEVVPNGDLVRRD, corresponding to amino acid residues 201-215 of rat CALCR

Isotype: IgG

Application Details

Application Notes:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: 1:50

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7234900)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Preservative: Without preservative

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for Calcitonin Receptor

Target: Calcitonin Receptor (CALCR)

Alternative Name: CALCR

Background:

Synonyms: CALCR, CT receptor, CT-R, C1A/C1B

Description: the calcitonin receptor (CTR) is a class B G-protein coupled receptor (GPCR) that signals via activation of cAMP and protein kinase C (PKC). It is one of 15 human class B GPCRs1,2. Apart from CTR, calcitonin receptor-like receptor (CTLR) is the only other B-class GPCR to bind calcitonin. To date, there are three known human CTR mRNA isoforms arising from alternative splicing3.Calcitonin itself is a peptide hormone that contributes to bone calcification by direct inhibition of osteoclasts which resorb the bony tissue. It is part of a six-member family that has varied functionalities. By binding to receptor activity modifying proteins (RAMPs), CTR and CTLR can form receptors to every member of the calcitonin family. For instance, RAMP1 and CTR construct the calcitonin gene-related peptide (CGRP) receptor.Both CTR and CTLR have seven transmembrane domains, an intracellular C-terminal, and an extracellular N-terminal. To activate the receptors, their N-terminal must first capture the C-terminal of the ligand and then carried to the transmembrane loops where it bestows a conformational change upon them.Besides the bone, CTR has prominent roles in the kidney, CNS, placenta, ovaries, sperm, lung, and in the brain4,5.In osteoclasts, the expression of CTRs declines with age. Interestingly, polymorphism of the CTR gene is strongly associated with decreased fracture-risk in post-menopausal women3,6.

Gene ID: 116506

UniProt: P32214

Pathways: cAMP Metabolic Process