SSTR5 antibody (Extracellular, N-Term)

Catalog No. ABIN7885531

The Rabbit Polyclonal anti-SSTR5 antibody is suitable to detect SSTR5 in samples from Human, Mouse and Rat. It has been validated for WB, IHC, IC, IF and LCI.

Quick Overview for SSTR5 antibody (Extracellular, N-Term) (ABIN7885531)

Target: SSTR5 (Somatostatin Receptor 5 (SSTR5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SSTR5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunochromatography (IC), Immunofluorescence (IF), Live Cell Imaging (LCI)

Grade: Carrier-free

Product Details anti-SSTR5 Antibody

Binding Specificity: AA 2-15, Extracellular, N-Term

Purpose: A Polyclonal Antibody to Somatostatin Receptor Type 5

Predicted Reactivity: Mouse - identical, human - 12,14 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogen: CEPLSLASTPSWNAS, corresponding to amino acid residues 2-15 of rat SSTR5

Isotype: IgG

Application Details

Application Notes:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: 1:50

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7237251)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Preservative: Without preservative

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for SSTR5

Target: SSTR5 (Somatostatin Receptor 5 (SSTR5))

Alternative Name: SSTR5

Background:

Synonyms: SSTR5, SS5R, Smstr5, SST5

Description: Somatostatin (SST) is a small cyclic peptide that was first identified as a powerful inhibitor of the secretion of various hormones including growth hormone (GH), thyroid-stimulating hormone (TSH) and prolactin from the pituitary, as well as almost every major hormone from the intestinal tract. SST consists of two major bioactive forms, SST-14 and the N-terminus extended peptide SST-28, that can be produced by a wide variety of neuroendocrine, inflammatory and immune cells. In target cells, SST induces a variety of physiological functions that include neuromodulation, cell secretion, cell proliferation and smooth muscle contractility.SST acts on its multiple cell targets via a family of six receptors that originate from five genes: SSTR1, SSTR2a, SSTR2b, SSTRR3, SSTR4, SSTR5. The SSTRs are members of the G-protein coupled receptor superfamily and they modulate cell response via multiple second messenger systems such as inhibition of adenylate cyclase, modulation of conductance of ion channels and protein dephosphorylation.In contrast to SSTR1-4 that bind SST-14 and SST-28 with similar affinity, SSTR5 has a much greater affinity to SST-28 over SST-14.SSTRs are widely expressed in both the brain and peripheral tissues but with receptor subtype variations between the different cell types.Strong SSTR expression has been detected in a variety of human tumors including pancreatic, breast, lung and prostate cancers. In fact, SST has been shown to inhibit the growth of various normal and tumor cells. On this basis, several long lasting SST analogs have been developed and are being tested for use in several pathologies such as various cancers, acromegaly, immunoproliferative disorders, diabetic retinopathy, epilepsy and pain.SSTR5 is expressed in a variety of tissues and cells, including pancreas, colonic mucosa, small intestine, heart, and vascular smooth muscle cells.SSTR5 has been shown to mediate growth inhibition and cell proliferation, and to play an important role in cancer growth regulation as one of the most potent inhibitory receptors.

Gene ID: 25354

UniProt: P30938

Pathways: Carbohydrate Homeostasis