beta-2 Microglobulin antibody (AA 22-119) (HRP)

Catalog No. ABIN7972614

This Mouse Monoclonal antibody specifically detects beta-2 Microglobulin in WB, IHC and ELISA. It exhibits reactivity toward Human and Monkey.

Quick Overview for beta-2 Microglobulin antibody (AA 22-119) (HRP) (ABIN7972614)

Target: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Reactivity: Human, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This beta-2 Microglobulin antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 2H10

Product Details anti-beta-2 Microglobulin Antibody (HRP)

Binding Specificity: AA 22-119

Purpose: Anti-Beta 2 Microglobulin B2M Antibody (monoclonal, 2H10) HRP Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: Human Beta 2 Microglobulin shares 69.4%,74.5% amino acid (aa) sequence identity with mouse,rat Beta 2 Microglobulin,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Beta 2 Microglobulin recombinant protein (Position: Q22-M119). Human Beta 2 Microglobulin shares 69.4% and 74.5% amino acid (aa) sequence identity with mouse and rat Beta 2 Microglobulin, respectively.

Isotype: IgG2b

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for beta-2 Microglobulin

Target: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Alternative Name: B2M

Background:

Background: Beta-2 microglobulin also known as B2M is a component of MHC class I molecules, which are present on all nucleated cells (excludes red blood cells). In humans, the beta-2-microglobulin protein is encoded by the B2M gene. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.

Gene Full Name: beta-2-microglobulin

Gene ID: 567

UniProt: P61769

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process