CD46 antibody (N-Term) (APC)

Catalog No. ABIN7977028

The Rabbit Polyclonal anti-CD46 antibody is suitable to detect CD46 in samples from Mouse. It has been validated for FACS.

Quick Overview for CD46 antibody (N-Term) (APC) (ABIN7977028)

Target: CD46

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD46 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-CD46 Antibody (APC)

Binding Specificity: N-Term

Purpose: Anti-CD46 Antibody APC Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: different from the related human sequence by twelve amino acids,and from the related rat sequence by nine amino acids.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of mouse CD46, different from the related human sequence by twelve amino acids, and from the related rat sequence by nine amino acids.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for CD46

Target: CD46

Alternative Name: Cd46

Background:

Background: CD46 complement regulatory protein,?also known as?CD46 (cluster of differentiation?46) and?Membrane Cofactor Protein,?is a?protein?which in humans is encoded by the?CD46 gene. The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. And the encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.?

Gene Full Name: CD46 antigen, complement regulatory protein

Gene ID: 17221

UniProt: O88174

Pathways: Regulation of Actin Filament Polymerization