Choline Acetyltransferase antibody (AA 131-704) (FITC)

Catalog No. ABIN7979635

The Rabbit Polyclonal anti-Choline Acetyltransferase antibody is suitable to detect Choline Acetyltransferase in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for Choline Acetyltransferase antibody (AA 131-704) (FITC) (ABIN7979635)

Target: Choline Acetyltransferase (CHAT) (Choline O-Acetyltransferase (CHAT))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Choline Acetyltransferase antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Product Details anti-Choline Acetyltransferase Antibody (FITC)

Binding Specificity: AA 131-704

Purpose: Anti-Choline Acetyltransferase/CHAT Antibody FITC Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Choline Acetyltransferase/CHAT recombinant protein (Position: L131-S704).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Choline Acetyltransferase

Target: Choline Acetyltransferase (CHAT) (Choline O-Acetyltransferase (CHAT))

Alternative Name: CHAT

Background:

Background: Choline acetyltransferase(commonly abbreviated asChAT, but sometimesCAT) is atransferaseenzymeresponsible for the synthesis of theneurotransmitteracetylcholine. In humans, the choline acetyltransferase enzyme is encoded by theCHATgene. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform.

Gene Full Name: choline O-acetyltransferase

Gene ID: 1103

UniProt: P28329

Pathways: Skeletal Muscle Fiber Development