CRTC2 antibody (C-Term) (APC)

Catalog No. ABIN7981829

The APC-conjugated Rabbit Polyclonal anti-CRTC2 antibody (ABIN7981829) specifically detects CRTC2 in FACS. The antibody is reactive with Human samples.

Quick Overview for CRTC2 antibody (C-Term) (APC) (ABIN7981829)

Target: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRTC2 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-CRTC2 Antibody (APC)

Binding Specificity: C-Term

Purpose: Anti-TORC2/CRTC2 Antibody APC Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: different from the related rat sequence by three amino acids,and from the related mouse sequence by two amino acids.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human TORC2, different from the related rat sequence by three amino acids, and from the related mouse sequence by two amino acids.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for CRTC2

Target: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Alternative Name: CRTC2

Background:

Background: CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which in humans is encoded by the CRTC2 gene. This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5.

Gene Full Name: CREB regulated transcription coactivator 2

Sequence Similarities: Belongs to the TORC family.

Gene ID: 200186

UniProt: Q53ET0

Pathways: AMPK Signaling, Carbohydrate Homeostasis