Crossover junction endonuclease EME1 (EME1) (C-Term) antibody (Cy3)

Catalog No. ABIN7981845

This Rabbit Polyclonal antibody specifically detects Crossover junction endonuclease EME1 in FACS. It exhibits reactivity toward Human and Rat.

Quick Overview for Crossover junction endonuclease EME1 (EME1) (C-Term) antibody (Cy3) (ABIN7981845)

Target: Crossover junction endonuclease EME1 (EME1)

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Cy3

Application: Flow Cytometry (FACS)

Product Details

Binding Specificity: C-Term

Purpose: Anti-EME1 Antibody Cy3 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: different from the related mouse sequence by five amino acids.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human EME1, different from the related mouse sequence by five amino acids.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details

Target: Crossover junction endonuclease EME1 (EME1)

Alternative Name: EME1

Background:

Background: Crossover junction endonuclease EME1 is an enzyme that in humans is encoded by the EME1 gene. It is mapped to 17q21.33. This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. Also, this protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants.

Gene Full Name: essential meiotic structure-specific endonuclease 1

Gene ID: 146956

UniProt: Q96AY2